Sepsis- The Dilemma Continues
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چکیده
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection [1]. Sepsis syndrome represents the body’s host response to infection. Classically, sepsis has been defined and classified as systemic inflammatory response syndrome (SIRS), sepsis and septic shock based on diagnostic criteria derived from the systemic response to inflammation (Figure 1). However, recently the term ‘severe sepsis’ has been dropped from the definitions to better identify, manage, report and improve outcomes [1]. The prevalence of sepsis is on the rise. Factors could be many; such as an ageing population, immunosuppression, evolving multidrug resistant pathogens, more people in the ICUs, as well as an increase in the number of low-birth-weight new-borns who are particularly at a high risk [2].
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